Isum Pharma

• Calutide Tablets - Product Information Calutide is used in the treatment of advanced prostate cancer in combination with LHRH analogue therapy. It is available in a blister pack of 10 tablets. Calutide Tablets is a non-steroidal androgen receptor inhibitor with no other known endocrine activity. Active Pharmaceutical Ingredient in Calutide Tablets
• Uses of Calutide Tablets Calutide is used in the treatment of advanced prostate cancer that has spread to other areas of the body. It is prescribed in combination with LHRH analogue therapy. Calutide is used also as monotherapy for early stages of prostate cancer. Dosage take once a day one tablet of Calutide at the same time each day either in the morning or evening. Take it with or without food. Take it regularly to get the most benefit from it.

Carboplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Carboplatin is used together with other cancer medications to treat ovarian cancer.

You should not receive this medication if you are allergic to carboplatin or similar medications such as oxaliplatin (Eloxatin) or cisplatin (Platinol). You should not receive carboplatin if you have severe bleeding or bone marrow suppression.

To make sure carboplatin is safe for you, tell your doctor if you have:

• liver disease;

• kidney disease;

• a weak immune system; or

• if you have received carboplatin in the past.

Do not use carboplatin if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether carboplatin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while being treated with carboplatin.

Carboplatin is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Carboplatin is usually given once every 4 weeks. Follow your doctor's instructions.

You may be given other medications to prevent nausea or vomiting while you are receiving carboplatin.

Carboplatin can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Your kidney and liver function may also need to be tested.

You may need to receive blood transfusions while you are being treated with carboplatin.

Carboplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Carboplatin is used together with other cancer medications to treat ovarian cancer.

Carboplatin is a cancer medication used in chemotherapy combinations to treat ovarian cancer.

You should not receive carboplatin if you have severe bleeding or bone marrow suppression.

Carboplatin can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before you receive carboplatin, tell your doctor about all other medications you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.

Carboplatin can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

You should not receive this medication if you are allergic to carboplatin or similar medications such as oxaliplatin (Eloxatin) or cisplatin (Platinol). You should not receive carboplatin if you have severe bleeding or bone marrow suppression.

To make sure carboplatin is safe for you, tell your doctor if you have:

• liver disease;

• kidney disease;

• a weak immune system; or

• if you have received carboplatin in the past.

Do not use carboplatin if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

It is not known whether carboplatin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while being treated with carboplatin.

Product Description:

Tamoxifen blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow.

Tamoxifen is used to treat some types of breast cancer in men and women. It is also used to lower a woman's chance of developing breast cancer if she has a high risk (such as a family history of breast cancer).

Before using this medicine, tell your doctor if you have liver disease, high triglycerides (a type of fat in the blood), a history of cataract, or a history of stroke or blood clot. Also tell your doctor if you if you are receiving chemotherapy or radiation treatment.

If you are taking tamoxifen to reduce your risk of breast cancer, you may need to take your first dose while you are having a menstrual period. You may also need to have a pregnancy test before you start taking this medicine, to make sure you are not pregnant. Follow your doctor's instructions.

Paclitaxel is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Paclitaxel is used to treat breast cancer, ovarian cancer, and lung cancer. It is also used to treat AIDS-related Kaposi's sarcoma.

You should not receive this medication if you are allergic to paclitaxel, or to other medications that contain an ingredient called Cremophor EL (polyoxyethylated castor oil). This includes cyclosporine and teniposide.

To make sure paclitaxel is safe for you, tell your doctor if you have:

• HIV, AIDS, or Kaposi's sarcoma;

• heart disease;

• high blood pressure; or

• liver disease.

Paclitaxel is injected into a vein through an IV. A healthcare provider will give you this injection. You may be given other medications to prevent an allergic reaction while you are receiving paclitaxel.

Paclitaxel is usually given once every 3 weeks. Follow your doctor's dosing instructions very carefully.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving paclitaxel.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when paclitaxel is injected.

Paclitaxel can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.

Additional Information:

• Pay Mode Terms: T/T (Bank Transfer)

Pemetrexed is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Pemetrexed is used to treat non-small cell lung cancer after other cancer medications have been tried without successful treatment.

Pemetrexed is also used with another medication called cisplatin to treat mesothelioma, a form of lung cancer associated with exposure to asbestos.

Pemetrexed may also be used for purposes not listed in this medication guide.

You should not receive this medication if you are allergic to pemetrexed.

To make sure pemetrexed is safe for you, tell your doctor if you have:

• kidney disease (especially if you take ibuprofen (Advil, Motrin) or other nonsteroidal anti-inflammatory drugs, or NSAIDs);

• liver disease;

• a weak immune system; or

• excess fluid in the space around your lung, liver, or other internal organs, including pleural effusion (fluid around the lungs) or ascites (fluid around the liver).

Do not use pemetrexed if you are pregnant. It could harm the unborn baby. Use effective birth control to avoid pregnancy during your treatment with pemetrexed. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.

It is not known whether pemetrexed passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using pemetrexed.

• Erlotinib has shown a survival benefit in the treatment of lung cancer in phase III trials. The SATURN (Sequential in UnresectableNSCLC) study found that erlotinib added to chemotherapy improved overall survival by 19%, and improved progression-free survival (PFS) by 29%, when compared to chemotherapy alone. In lung cancer, erlotinib has been shown to be effective in patients with or without EGFR mutations, but appears to be more effective in patients with EGFR mutations.

Sorafenib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Sorafenib is used to treat liver cancer, thyroid cancer, or a type of kidney cancer called advanced renal cell carcinoma.

Sorafenib may also be used for purposes not listed in this medication guide.

You should not use sorafenib if you are allergic to it, or if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).

To make sure sorafenib is safe for you, tell your doctor if you have:

• kidney or liver problems other than cancer;

• lung cancer;

• a bleeding or blood clotting disorder such as hemophilia;

• high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain;

• a personal or family history of Long QT syndrome;

• a history of stroke or heart attack; or

• any allergies.

Do not use sorafenib if you are pregnant. It could harm the unborn baby.

Use birth control to prevent pregnancy while you are receiving sorafenib, whether you are a man or a woman. Tell your doctor right away if a pregnancy occurs while either parent is taking this medication. Keep using birth control for at least 2 weeks after your treatment ends.

It is not known whether sorafenib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Sorafenib is usually taken 2 times per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Take sorafenib on an empty stomach, at least 1 hour before or 2 hours after eating.

Do not crush, chew, or break a sorafenib tablet. Swallow it whole with water.

Your blood pressure will need to be checked often.

If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using sorafenib. You may need to stop using the medicine for a short time.

Pomalidomide affects the immune system. It promotes immune responses to help slow tumor growth.

Pomalidomide is used to treat multiple myeloma (cancer resulting from a progressive blood disease). Pomalidomide is usually given after at least two other medications have been tried without success.

Pomalidomide is available only from a certified pharmacy under a special program called Pomalyst REMS. Your doctor must be registered in the program in order to prescribe pomalidomide for you. You must be registered in the program and sign documents stating that you understand the dangers of this medication and that you agree to use birth control measures as required by the program.

Pomalidomide may also be used for purposes not listed in this medication guide.

Use birth control to prevent pregnancy, whether you are a man or a woman. For women: Use two forms of birth control beginning 4 weeks before you start taking pomalidomide and ending 4 weeks after you stop taking it. For men: Use a condom to prevent pregnancy during your treatment, and for up to 28 days after your treatment ends.

Pomalidomide may cause blood clots. Stop using pomalidomide and call your doctor at once if you have symptoms such as chest pain, wheezing, coughing up blood, or if you have pain, swelling, warmth, or redness in one or both legs.

ERLONAT is a targeted therapy. Erlonat is classified as a epidermal growth factor receptor (EGFR) inhibitor - protein-tyrosine kinase inhibitor. It works by helping to stop cancer cells from growing.

MEDICINE USES:

Erlonat medicine is used for :

· Treatment of patients with locally advanced or metastatic non-small cell lung cancer (NSCLC).

· Treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer.

Erlonat works by slowing cancer cell growth. It binds to a certain protein (epidermal growth factor receptor-EGFR) in some tumors.

ERLONAT COMMON SIDE EFFECTS:

Nausea, vomiting, loss of appetite, mouth sores, dry skin, eye dryness/irritation, or unusual eyelash growth may occur. Changes in diet such as eating several small meals or limiting activity may help lessen the chance of nausea. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

Tell your doctor right away if any of these rare but very serious side effects occur: signs of kidney problems (such as change in the amount of urine), black stools, vomit that looks like coffee grounds, easy bleeding/bruising, stomach/abdominal pain, yellowing eyes or skin, dark urine, unusual fatigue, signs of infection (e.g., fever, chills, persistent sore throat), eye pain, vision changes.

Sorafenib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Sorafenib is used to treat liver cancer, thyroid cancer, or a type of kidney cancer called advanced renal cell carcinoma.

You should not use sorafenib if you are allergic to it, or if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).

To make sure sorafenib is safe for you, tell your doctor if you have:

• kidney or liver problems other than cancer;

• lung cancer;

• a bleeding or blood clotting disorder such as hemophilia;

• high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain;

• a personal or family history of Long QT syndrome;

• a history of stroke or heart attack; or

• any allergies.

Do not use sorafenib if you are pregnant. It could harm the unborn baby.

Use birth control to prevent pregnancy while you are receiving sorafenib, whether you are a man or a woman. Tell your doctor right away if a pregnancy occurs while either parent is taking this medication. Keep using birth control for at least 2 weeks after your treatment ends.

Capecitabine is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Capecitabine is used to treat colon cancer, and breast or colorectal cancer that has spread to other parts of the body.

Capecitabine is often used in combination with other cancer medications and/or radiation treatments.

You should not take this medicine if you are allergic to capecitabine or fluorouracil (Adrucil), or if you have:

• severe kidney disease; or

• a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency.

To make sure capecitabine is safe for you, tell your doctor if you have any of these conditions:

• kidney disease;

• bleeding or blood clotting disorder such as hemophilia;

• liver disease;

• a history of coronary artery disease; or

• if you take a blood thinner (\, Coumadin, Jantoven).

Do not use capecitabine if you are pregnant. It could harm the unborn baby.

Use birth control to prevent pregnancy while you are taking capecitabine, whether you are a man or a woman. Tell your doctor if a pregnancy occurs during treatment.

It is not known whether capecitabine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking capecitabine.

Capecitabine is usually taken twice per day. Follow the directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Capecitabine is given in a 3-week treatment cycle, and you may only need to take the medicine during the first 2 weeks of each cycle. Your doctor will determine how long to treat you with capecitabine.

Capecitabine is only part of a treatment program that may also include other medications taken on different schedules. Follow your doctor's dosing instructions very carefully.

Capecitabine should be taken with food or within 30 minutes after eating a meal.

Take capecitabine with a full glass (8 ounces) of water.

Call your doctor if you are sick with vomiting or diarrhea, if you are unable to eat because of stomach illness, or if you are sweating more than usual. Prolonged illness can lead to dehydration or kidney failure.

Aprepitant blocks the actions of chemicals in the body that trigger nausea and vomiting.

Aprepitant is used in adults and children to prevent nausea and vomiting caused by cancer chemotherapy. Aprepitant is also used (only in adults) to prevent nausea and vomiting that may be caused by surgery.

Aprepitant is given ahead of time and will not treat nausea or vomiting that you already have.

Aprepitant capsules are for use in adults and children who are at least 12 years old. Aprepitant oral suspension (liquid) can be given to adults and children as young as 6 months old.

You should not use aprepitant if you are allergic to it, or if you take another medicine called pimozide (Orap). Aprepitant can cause unwanted or dangerous effects when used with pimozide.

To make sure aprepitant is safe for you, tell your doctor if you have:

• liver disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Aprepitant can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy, and for 1 month after your last dose.

It is not known whether aprepitant passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Capecitabine is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body.

Capecitabine is used to treat colon cancer, and breast or colorectal cancer that has spread to other parts of the body.

Capecitabine is often used in combination with other cancer medications and/or radiation treatments.

You should not take this medicine if you are allergic to capecitabine or fluorouracil (Adrucil), or if you have:

• severe kidney disease; or

• a metabolic disorder called DPD (dihydropyrimidine dehydrogenase) deficiency.

To make sure capecitabine is safe for you, tell your doctor if you have any of these conditions:

• kidney disease;

• bleeding or blood clotting disorder such as hemophilia;

• liver disease;

• a history of coronary artery disease; or

• if you take a blood thinner (, Coumadin, Jantoven).

Use birth control to prevent pregnancy while you are taking capecitabine, whether you are a man or a woman. Tell your doctor if a pregnancy occurs during treatment.

It is not known whether capecitabine passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking capecitabine.

Epirubicin is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Epirubicin is used to treat breast cancer.

uncontrolled infection, severe liver disease, severe heart problems, or if you have recently had a heart attack.

Epirubicin may cause dangerous effects on your heart. Call your doctor at once if you have chest pain, shortness of breath (even with mild exertion), swelling, or rapid weight gain.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when epirubicin is injected. Call your doctor if you have irritation or skin changes where the injection was given.

Epirubicin can lower blood cells that help your body fight infections and help your blood to clot. You may get an infection or bleed more easily. Call your doctor if you have unusual bruising or bleeding, or signs of infection (fever, chills, body aches).

Using epirubicin may increase your risk of other types of cancer, such as leukemia.

Before you are treated with epirubicin, tell your doctor about all other cancer medications and treatments you have received, including radiation.

You should not use this medication if you are allergic to epirubicin or similar medications (Cerubidine, Adriamycin, Idamycin, Novantrone), or if you have:

• an untreated or uncontrolled infection (including mouth sores);

• severe liver disease;

• severe heart problems; or

• if you have recently had a heart attack.

To make sure epirubicin is safe for you, tell your doctor if you have:

• liver or kidney disease;

• bone marrow suppression;

• heart disease; or

• if you have been treated before with doxorubicin, daunorubicin, epirubicin, idarubicin, or mitoxantrone.

Using epirubicin may increase your risk of developing other types of cancer, such as leukemia. Talk with your doctor about your specific risk.

Do not use epirubicin if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment.

Use birth control to prevent pregnancy while you are receiving epirubicin, whether you are a man or a woman. Epirubicin use by either parent may cause birth defects.

It is not known whether epirubicin passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using epirubicin.

Lapatinib is a cancer medicine that interferes with the growth and spread of cancer cells in the body.

Lapatinib is used to treat a certain type of hormone-related breast cancer that has progressed or spread after treatment with other cancer medicines.

In postmenopausal women, lapatinib is given in combination with a hormonal medicine called letrozole (Femara). In others, lapatinib is given together with a cancer medicine called capecitabine .

You should not use lapatinib if you are allergic to it.

To make sure lapatinib is safe for you, tell your doctor if you have:

• heart disease;

• liver disease (lapatinib can cause severe or fatal liver problems);

• an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); or

• a personal or family history of long QT syndrome.

Do not use lapatinib if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine. Tell your doctor right away if you become pregnant.

It is not known whether lapatinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are taking this medicine.

Thalidomide affects the immune system. It promotes immune responses to help slow tumor growth.

Thalidomide is used together with dexamethasone to treat multiple myeloma (bone marrow cancer). Thalidomide is also used to treat and prevent moderate to severe skin lesions caused by leprosy.

Thalidomide is available only from a certified pharmacy under a special program called REMS. You must be registered in the program and agree to use birth control as required. You will be limited to a 28-day supply of thalidomide each time your prescription is refilled.

Thalidomide can cause severe, life-threatening birth defects or death of a baby if the mother or the father is taking this medicine at the time of conception or during pregnancy. Even one dose of thalidomide can cause major birth defects of the baby's arms and legs, bones, ears, eyes, face, and heart. Never use thalidomide if you are pregnant. Tell your doctor right away if your period is late while taking thalidomide.

For Women: If you have not had a hysterectomy, you will be required to use two reliable forms of birth control beginning 4 weeks before you start taking thalidomide and ending 4 weeks after you stop taking it. Even women with fertility problems are required to use birth control while taking this medicine. You must also have a negative pregnancy test at 10 to 14 days before treatment and again at 24 hours before. While you are taking thalidomide, you will have a pregnancy test every 2 to 4 weeks.

Letrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Letrozole is used to treat breast cancer in postmenopausal women. It is often given to women who have been taking tamoxifen (Nolvadex, Soltamox) for 5 years.

You should not use letrozole if you are allergic to it, or if you have:

• if you have not gone completely through menopause.

To make sure letrozole is safe for you, tell your doctor if you have:

• liver disease (especially cirrhosis);

• osteoporosis, osteopenia (low bone mineral density);

• high cholesterol; or

• if you also take tamoxifen.

Anastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen

Anastrozole may not work as well if you take it together with estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings).

Anastrozole may increase your risk of a stroke or blood clot. Call your doctor at once if you have sudden numbness or weakness, (especially on one side of the body), sudden severe headache, slurred speech, or problems with vision or balance.

Trastuzumab is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Trastuzumab is used to treat certain types of breast cancer or stomach cancer. Other cancer medicines are sometimes used in combination with trastuzumab.

To make sure trastuzumab is safe for you, tell your doctor if you have ever had:

• heart disease;

• congestive heart failure;

• a heart attack; or

• any allergies or breathing problems.

Trastuzumab can cause heart failure, especially if you have heart disease or if you are also receiving certain other cancer medicines (such as daunorubicin, doxorubicin, epirubicin, or idarubicin)

Do not use trastuzumab if you are pregnant. It could harm the unborn baby. Tell your doctor if you become pregnant during treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 7 months after your treatment ends.

If you become pregnant while using this medicine or within 7 months after you stop, your name may need to be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of trastuzumab on the baby.

It is not known whether trastuzumab passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine

Anastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen

You should not use this medication if you are allergic to anastrozole, if you are breast-feeding a baby, or if you have not yet completed menopause. Anastrozole is not for use in men or children.

To make sure anastrozole is safe for you, tell your doctor if you have:

• heart disease;

• circulation problems;

• a history of stroke or blood clot;

• severe liver disease;

• high cholesterol; or

• osteoporosis or low bone mineral density.

Additional Information:

• Pay Mode Terms: T/T (Bank Transfer)
• Port of Dispatch: Mumbai

Imatinib interferes with the growth of some cancer cells.

Imatinib is used to treat certain types of leukemia (blood cancer), bone marrow disorders, and skin cancer. Imatinib is also used to treat certain tumors of the stomach and digestive system.

You should not use imatinib if you are allergic to it.

To make sure imatinib is safe for you, tell your doctor if you have ever had:

• liver disease (especially hepatitis B);

• kidney disease;

• underactive thyroid, recent or upcoming thyroid surgery;

• heart disease, congestive heart failure;

• a stomach ulcer or bleeding;

• diabetes; or

• chemotherapy.

ause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 14 days after your last dose.

You may need to have a negative pregnancy test before starting this treatment.

Imatinib can pass into breast milk and may cause side effects in the nursing baby. You should not breast-feed while taking imatinib and for at least 1 month after your last dose.

Imatinib interferes with the growth of some cancer cells.

Imatinib is used to treat certain types of leukemia (blood cancer), bone marrow disorders, and skin cancer. Imatinib is also used to treat certain tumors of the stomach and digestive system.

You should not use imatinib if you are allergic to it.

To make sure imatinib is safe for you, tell your doctor if you have ever had:

• liver disease (especially hepatitis B);

• kidney disease;

• underactive thyroid, recent or upcoming thyroid surgery;

• heart disease, congestive heart failure;

• a stomach ulcer or bleeding;

• diabetes; or

• chemotherapy.

ause birth defects. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 14 days after your last dose.

You may need to have a negative pregnancy test before starting this treatment.

Imatinib can pass into breast milk and may cause side effects in the nursing baby. You should not breast-feed while taking imatinib and for at least 1 month after your last dose.

Abiraterone works by reducing androgen production in the body. Androgens are male hormones that can promote tumor growth in the prostate gland.

Abiraterone is used together with prednisone to treat prostate cancer that has spread to other parts of the body. This medicine is used in men whose prostate cancer cannot be treated with surgery or other medicines.

You should not use abiraterone if you are allergic to it, or if you have ever had:

• severe liver disease.

To make sure abiraterone is safe for you, tell your doctor if you have:

• liver disease;

• heart disease, high blood pressure;

• problems with your adrenal gland or pituitary gland;

• low levels of potassium in your blood;

• fluid retention;

• a heart attack; or

• if you take medicine to treat seizures, tuberculosis, HIV or AIDS.

While you are taking abiraterone and for at least 1 week after your treatment ends:

• If your sexual partner is pregnant--Use a condom to prevent transfer of this medication to her.

• If your sexual partner could become pregnant--Use a condom plus another form of effective birth control to prevent pregnancy.

Although abiraterone is not for use by women, this medicine can harm an unborn baby or cause birth defects. Abiraterone tablets should not be handled by a woman who is pregnant or who may become pregnant. If this cannot be avoided, the woman should wear latex gloves.

It is not known whether abiraterone passes into breast milk or if it could harm a nursing baby. Abiraterone should not be used by a woman who is breast-feeding a baby.

Abiraterone is not approved for use by anyone younger than 18 years old.

Cyclophosphamide is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Cyclophosphamide is used to treat several types of cancer. Cyclophosphamide is also used to treat certain cases of nephrotic syndrome (kidney disease) in children.

You should not use cyclophosphamide if you are allergic to it, or if you have severe bone marrow suppression.

To make sure cyclophosphamide is safe for you, tell your doctor if you have:

• an active or recent infection;

• a weak immune system (caused by disease or by using certain medicines);

• heart disease;

• kidney disease;

• liver disease;

• if you are receiving other cancer treatments; or

• if you have ever received radiation treatment.

Using cyclophosphamide may increase your risk of developing other types of cancer, such as bladder cancer. Talk with your doctor about your specific risk.

Do not use cyclophosphamide if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Cyclophosphamide is sometimes given as a pill or liquid. Cyclophosphamide may also be given as an injection into a vein through an IV. You will receive the injection in a clinic or hospital setting.

Drink plenty of liquids while you are using cyclophosphamide, to prevent harmful effects on your bladder.

Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

Cyclophosphamide can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often.

If you need surgery, tell the surgeon ahead of time that you are using cyclophosphamide. You may need to stop using the medicine for a short time.

Ask your doctor or pharmacist how to safely handle this medicine. Cyclophosphamide can be harmful if it gets on your skin. If this occurs, wash thoroughly with soap and water.

Store cyclophosphamide tablets at room temperature away from moisture and heat.

Store the liquid medicine in the refrigerator, do not freeze. Throw away any unused liquid after 14 days.

nastrozole lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body.

Anastrozole is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen(Nolvadex, Soltamox).

Anastrozole may not work as well if you take it together with estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings).

Anastrozole may increase your risk of a stroke or blood clot. Call your doctor at once if you have sudden numbness or weakness, (especially on one side of the body), sudden severe headache, slurred speech, or problems with vision or balance.

You should not use this medication if you are allergic to anastrozole, if you are breast-feeding a baby, or if you have not yet completed menopause. Anastrozole is not for use in men or children.

To make sure anastrozole is safe for you, tell your doctor if you have:

• heart disease;

• circulation problems;

• a history of stroke or blood clot;

• severe liver disease;

• high cholesterol; or

• osteoporosis or low bone mineral density.

Anastrozole can decrease bone mineral density, which may increase your risk of developing osteoporosis. Your bone mineral density may need to be tested before and during treatment with anastrozole.

Sorafenib is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Sorafenib is used to treat liver cancer, thyroid cancer, or a type of kidney cancer called advanced renal cell carcinoma.

You should not use sorafenib if you are allergic to it, or if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).

To make sure sorafenib is safe for you, tell your doctor if you have:

• kidney or liver problems other than cancer;

• lung cancer;

• a bleeding or blood clotting disorder such as hemophilia;

• high blood pressure (hypertension), heart disease, slow heartbeats, congestive heart failure, chest pain;

• a personal or family history of Long QT syndrome;

• a history of stroke or heart attack; or

• any allergies.

Do not use sorafenib if you are pregnant. It could harm the unborn baby.

Use birth control to prevent pregnancy while you are receiving sorafenib, whether you are a man or a woman. Tell your doctor right away if a pregnancy occurs while either parent is taking this medication. Keep using birth control for at least 2 weeks after your treatment ends.